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Fundação de Amparo à Pesquisa do Estado de São Paulo Although neglected diseases account for 11% of the global disease burden, they are targeted by only a small proportion of the new drugs developed every year. Between January 2012 and September 2018, a total of 256 new drugs entered the market, but only eight (3.1%) were designed to treat neglected diseases. This value exceeds the proportion for 1975-99, which was 1.1%, but falls short of the 4.3% mark recorded for 2000-11. The term [...]

Researchers used C. elegans as an animal model to investigate the importance of certain human genes for the treatment of schizophrenia.

Fundação de Amparo à Pesquisa do Estado de São Paulo Summary: Dysregulation of the signaling pathway known as the beta-catenin-dependent Wnt can also cause embryo malformation and contribute for the development of breast and cervical cancer. FULL STORY Cells in humans and other vertebrates, as well as invertebrates, have signaling pathways that play essential roles in embryo development, cell proliferation and tissue structuring. Dysregulation in one of these signaling pathways, known [...]

Fundação de Amparo à Pesquisa do Estado de São Paulo Summary: The role played by symbiotic microorganisms isolated from the skin of anurans has been discovered by researchers in Brazil. Brazilian scientists have discovered that the strong odor released by some amphibian species is produced by bacteria and that attracting a mate is one of its purposes. The bacteria in question are a noteworthy example of symbiosis as they assist in the animal's mating process. A paper recounting the [...]

Fundação de Amparo à Pesquisa do Estado de São Paulo Summary: Researchers describe the use of 13 molecular tools for measuring different intracellular signaling pathways and evaluating the action mechanisms of new drugs. FULL STORY Canadian researchers, working in partnership with Brazilian colleagues, have developed 13 bioluminescence sensors for use in testing the effectiveness of new medical drugs in the laboratory. The study, published in the journal Science Signaling, paves the [...]

Fundação de Amparo à Pesquisa do Estado de São Paulo Summary: Reconstitution of Amoebozoa's evolution shows significant Precambrian species diversity. This study changes the view of how life evolved in the very remote past and deepens the understanding of current climate change. FULL STORY Reconstitution of Amoebozoa's evolution shows significant Precambrian species diversity. This study changes the view of how life evolved in the very remote past and deepens the understanding of [...]

Fundação de Amparo à Pesquisa do Estado de São Paulo Summary: A structure comprising a molybdenum disulfide monolayer on an azobenzene substrate could be used to build a highly compactable and malleable quasi-two-dimensional transistor powered by light. FULL STORY Materials that are hybrid constructions (combining organic and inorganic precursors) and quasi-two-dimensional (with malleable and highly compactable molecular structures) are on the rise in several technological applications, [...]

Fundação de Amparo à Pesquisa do Estado de São Paulo A study identifies changes to neutrophils that appear to explain why people suffering from obesity and type 2 diabetes are more likely to contract infectious diseases. FULL STORY People who suffer from obesity and type 2 diabetes are more likely to become victims of infectious diseases. Both conditions affect the immune system and hence increase the risk of infections. Scientists have long sought a deeper understanding of the mechanism [...]

Fundação de Amparo à Pesquisa do Estado de São Paulo Summary: Lake systems existing in regions over 10 million years ago survived the Amazon River reversal due to Andean uplift. FULL STORY A land of giants. This is the best definition for Lake Pebas, a mega-wetland that existed in western Amazonia during the Miocene Epoch, which lasted from 23 million to 5.3 million years ago. The Pebas Formation was the home of the largest caiman and gavialoid crocodilian ever identified, both of [...]