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A recent study conducted in Brazil has shed light on a crucial aspect of pancreatic cancer progression, unveiling the pivotal role played by the protein periostin and stellate pancreatic cells in facilitating the infiltration of nerves and early spread of the disease, thereby elevating the risk of metastasis. This groundbreaking research has elucidated how the tumor orchestrates the reprogramming of adjacent healthy tissue, endowing it with a heightened capacity for invasion. Such a mechanism [...]

An artificial saliva in the form of a mouthwash, produced with the CANECPI-5 protein extracted from sugarcane and modified in a laboratory, can aid in treating teeth in patients with head and neck cancer. In these cases, radiotherapy very close to the mouth can destroy salivary glands and compromise saliva production, which is essential for controlling bacteria and disease. According to research conducted at the Bauru School of Dentistry at the University of São Paulo (FOB-USP) in Brazil, [...]

A Brazilian study involving nearly 900 participants under the age of 40 reinforces the idea that premature lung aging is linked not only to smoking but also to factors such as obesity and systemic inflammation. These two conditions may even be associated with an increased risk of developing chronic obstructive pulmonary disease (COPD). Also known as “smoker’s disease,” COPD is an irreversible condition characterized by inflammation and thickening of the airways. This leads to shortness [...]

Hormonal fluctuations throughout a woman’s life are among the factors that most influence the immune system. Like a seesaw, variations in estrogen and progesterone affect cellular levels and alter the immune and inflammatory profiles. For example, inflammatory activity is most intense in the days leading up to the menstrual period (luteal phase). During menopause, a drop in sex hormones promotes a pro-inflammatory state. Despite our understanding of the relationship between hormonal [...]

Researchers supported by FAPESP recorded lemon sharks (Negaprion brevirostris) preying on an invasive species, the jaguar cichlid (Parachromis managuensis), for the first time. This observation was made in Sueste Bay in March 2024. Sueste Bay is a well-known shark feeding ground in the Brazilian archipelago of Fernando de Noronha.   The study was published in the journal Environmental Biology of Fishes.  The event was considered unlikely because Sueste Bay is a sea inlet with [...]

A study conducted at the State University of Campinas (UNICAMP) in the state of São Paulo, Brazil, has proven the efficiency of a sustainable process for extracting isoflavones from soybean meal that increases their bioavailability. Isoflavones are used in foods, cosmetics, and supplements due to their health benefits, including combating neurodegenerative and cardiovascular diseases, type 1 and type 2 diabetes, hyperglycemia, and exhibiting anticancer, antimicrobial, and antioxidant [...]

 The cost of forest restoration is a considerable obstacle, sparking discussions in recent years about how to make it economically viable. Since native wood management, carbon credits, and payment for ecosystem services are long-term solutions – the latter two with a nascent market – a group of researchers proposes exploiting non-timber forest products with added value to generate income from reforestation areas. In an article published in the journal Ambio, a group led by [...]

Agência FAPESP* – A study conducted at the University of São Paulo (USP) by researchers from the Nucleus of Analysis and Synthesis of Nature-Based Solutions (BIOTA Synthesis), a FAPESP Science Center for Development (SCD), identified approximately 410,000 hectares in the state of São Paulo, Brazil, with potential for forest restoration in urban fringe areas. These peripheral areas of urban centers are characterized by diverse land uses, such as residential neighborhoods, agricultural [...]

Two recently published studies led by Brazilian scientists reveal the key roles of multifunctional proteins, STIP1 and Maspin, in vital cellular processes. The results demonstrate new protein functions that help clarify how cells maintain their shape, communicate, and renew themselves. These findings contribute to new studies on cancer, embryogenesis, and potential applications in regenerative medicine. According to one of the studies, STIP1 plays a central role in embryonic development [...]